Calcium enhances Salmonella typhimurium invasion of HeLa cells

David W. Niesel; Johnny W. Peterson

doi:10.1111/j.1574-6968.1987.tb02215.x

Calcium enhances Salmonella typhimurium invasion of HeLa cells

David W. Niesel, Johnny W. Peterson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.

Original language	English (US)
Pages (from-to)	299-304
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	41
Issue number	3
DOIs	https://doi.org/10.1111/j.1574-6968.1987.tb02215.x
State	Published - May 1987
Externally published	Yes

Keywords

Calcium
HeLa cell invasion
Salmonella typhimurium
Virulence

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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10.1111/j.1574-6968.1987.tb02215.x

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title = "Calcium enhances Salmonella typhimurium invasion of HeLa cells",

abstract = "Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.",

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year = "1987",

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AU - Niesel, David W.

AU - Peterson, Johnny W.

PY - 1987/5

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N2 - Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.

AB - Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.

KW - Calcium

KW - HeLa cell invasion

KW - Salmonella typhimurium

KW - Virulence

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Calcium enhances Salmonella typhimurium invasion of HeLa cells

Abstract

Keywords

ASJC Scopus subject areas

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