Calcium enhances Salmonella typhimurium invasion of HeLa cells

David W. Niesel, Johnny W. Peterson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalFEMS Microbiology Letters
Issue number3
StatePublished - May 1987
Externally publishedYes


  • Calcium
  • HeLa cell invasion
  • Salmonella typhimurium
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


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