Calcifying Nanoparticles (Nanobacteria): An Additional Potential Factor for Urolithiasis in Space Flight Crews

Jeffrey A. Jones, Neva Ciftcioglu, Josef F. Schmid, Yael R. Barr, Donald Griffith

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations

    Abstract

    Spaceflight-induced microgravity appears to be a risk factor for the development of urinary calculi, resulting in urolithiasis during and after spaceflight. Calcifying nanoparticles, or nanobacteria, multiply more rapidly in simulated microgravity and create external shells of calcium phosphate. The question arises whether calcifying nanoparticles are nidi for calculi and contribute to the development of clinically significant urolithiasis in those who are predisposed to the development of urinary calculi because of intrinsic or extrinsic factors. This case report describes a calculus recovered after flight from an astronaut that, on morphologic and immunochemical analysis (including specific monoclonal antibody staining), demonstrated characteristics of calcifying nanoparticles.

    Original languageEnglish (US)
    Pages (from-to)210.e11-210.e13
    JournalUrology
    Volume73
    Issue number1
    DOIs
    StatePublished - Jan 2009

    ASJC Scopus subject areas

    • Urology

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