Bone marrow cell cycle markers in inherited bone marrow failure syndromes

Mohamad M. Al-Rahawan; Blanche P. Alter; Barbara J. Bryant; M. Tarek Elghetany

doi:10.1016/j.leukres.2008.05.020

Bone marrow cell cycle markers in inherited bone marrow failure syndromes

Mohamad M. Al-Rahawan, Blanche P. Alter, Barbara J. Bryant, M. Tarek Elghetany

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.

Original language	English (US)
Pages (from-to)	1793-1799
Number of pages	7
Journal	Leukemia Research
Volume	32
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2008.05.020
State	Published - Dec 2008
Externally published	Yes

Keywords

Acute myeloid leukemia
Inherited bone marrow failure syndromes
Ki-67
Myelodysplastic syndrome
Survivin
p53

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2008.05.020

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title = "Bone marrow cell cycle markers in inherited bone marrow failure syndromes",

abstract = "Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.",

keywords = "Acute myeloid leukemia, Inherited bone marrow failure syndromes, Ki-67, Myelodysplastic syndrome, Survivin, p53",

author = "Al-Rahawan, {Mohamad M.} and Alter, {Blanche P.} and Bryant, {Barbara J.} and Elghetany, {M. Tarek}",

note = "Funding Information: We thank Mark H. Greene, MD for a critical review of the manuscript and Philip S. Rosenberg for providing statistical advice. We are grateful to the many patients and physicians who submitted bone marrow samples. This research was supported in part by the Intramural Research Program of the NIH and the National Cancer Institute and by the Center for Cancer and Blood Disorders at Children's National Medical Center, and by a grant from the Shwachman-Diamond Syndrome Foundation. ",

year = "2008",

month = dec,

doi = "10.1016/j.leukres.2008.05.020",

language = "English (US)",

volume = "32",

pages = "1793--1799",

journal = "Leukemia Research",

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T1 - Bone marrow cell cycle markers in inherited bone marrow failure syndromes

AU - Al-Rahawan, Mohamad M.

AU - Alter, Blanche P.

AU - Bryant, Barbara J.

AU - Elghetany, M. Tarek

N1 - Funding Information: We thank Mark H. Greene, MD for a critical review of the manuscript and Philip S. Rosenberg for providing statistical advice. We are grateful to the many patients and physicians who submitted bone marrow samples. This research was supported in part by the Intramural Research Program of the NIH and the National Cancer Institute and by the Center for Cancer and Blood Disorders at Children's National Medical Center, and by a grant from the Shwachman-Diamond Syndrome Foundation.

PY - 2008/12

Y1 - 2008/12

N2 - Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.

AB - Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.

KW - Acute myeloid leukemia

KW - Inherited bone marrow failure syndromes

KW - Ki-67

KW - Myelodysplastic syndrome

KW - Survivin

KW - p53

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JO - Leukemia Research

JF - Leukemia Research

IS - 12

ER -

Bone marrow cell cycle markers in inherited bone marrow failure syndromes

Abstract

Keywords

ASJC Scopus subject areas

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