Body composition of HIV/AIDS males: Effects of treatment with insulin- like growth factor (IGF-I) and growth hormone (GH)

K. J. Ellis; P. D.K. Lee; J. M. Pivarnik; J. G. Bukar; N. Gesundheit

doi:10.1016/S0969-8043(97)00084-5

Body composition of HIV/AIDS males: Effects of treatment with insulin- like growth factor (IGF-I) and growth hormone (GH)

K. J. Ellis, P. D.K. Lee, J. M. Pivarnik, J. G. Bukar, N. Gesundheit

Research output: Contribution to journal › Article › peer-review

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Abstract

A study was conducted to determine whether a pharmacological dose of insulin-like growth factor (IGF-I), administered with a low dose of growth hormone (GH), could produce an anabolic response in HIV/AIDS patients. The minimum effective GH dose needed, however, is not known. The GH dose selected was about an order of magnitude lower than that usually used for pharmacological treatment of GH deficiency. It was found that the moderate IGF-I dose combined with a low GH dose was insufficient to produce a detectable anabolic response as judged by the measurements of total body potassium (TBK) and total body nitrogen (TBN).

Original language	English (US)
Pages (from-to)	653-655
Number of pages	3
Journal	Applied Radiation and Isotopes
Volume	49
Issue number	5-6
DOIs	https://doi.org/10.1016/S0969-8043(97)00084-5
State	Published - May 1998
Externally published	Yes

ASJC Scopus subject areas

Radiation

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title = "Body composition of HIV/AIDS males: Effects of treatment with insulin- like growth factor (IGF-I) and growth hormone (GH)",

abstract = "A study was conducted to determine whether a pharmacological dose of insulin-like growth factor (IGF-I), administered with a low dose of growth hormone (GH), could produce an anabolic response in HIV/AIDS patients. The minimum effective GH dose needed, however, is not known. The GH dose selected was about an order of magnitude lower than that usually used for pharmacological treatment of GH deficiency. It was found that the moderate IGF-I dose combined with a low GH dose was insufficient to produce a detectable anabolic response as judged by the measurements of total body potassium (TBK) and total body nitrogen (TBN).",

author = "Ellis, {K. J.} and Lee, {P. D.K.} and Pivarnik, {J. M.} and Bukar, {J. G.} and N. Gesundheit",

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year = "1998",

month = may,

doi = "10.1016/S0969-8043(97)00084-5",

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T2 - Effects of treatment with insulin- like growth factor (IGF-I) and growth hormone (GH)

AU - Ellis, K. J.

AU - Lee, P. D.K.

AU - Pivarnik, J. M.

AU - Bukar, J. G.

AU - Gesundheit, N.

N1 - Funding Information: Acknowledgements--wWiseh to acknowledgRe. Shypailo, J. Joo, and J. Pratt for performintgh eb odyc omposition measuremenatnsd, L . Loddekefo re ditoriaal ssistanceT.h is work was supportebdy GenentechIn, c. and by the U.S. Departmenotf Agriculture,A griculturaRl esearchS ervice (CA# 58-6250-1-003T)h. e contentos f this publicationd o notn ecessarilrye flectth ev iewso r policieso f theU SDA, nor does mentiono f trade names,c ommerciapl roductso, r organizationims ply endorsement.

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Body composition of HIV/AIDS males: Effects of treatment with insulin- like growth factor (IGF-I) and growth hormone (GH)

Abstract

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