Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease

Salim S. Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K. Waller, Arshed A. Quyyumi, Ahmed K. Abdel-Latif

Research output: Contribution to journalArticlepeer-review

Abstract

Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalStem Cells Translational Medicine
Volume6
Issue number3
DOIs
StatePublished - Mar 2017
Externally publishedYes

Keywords

  • Ceramide-1 phosphate
  • Circulating progenitor cell
  • Coronary artery disease
  • Mobilization
  • Sphingosine-1 phosphate

ASJC Scopus subject areas

  • General Medicine

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