Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire

N. L. Forrester; R. C. Trout; E. A. Gould

doi:10.1016/j.virol.2006.09.011

Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire

N. L. Forrester, R. C. Trout, E. A. Gould

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

With the exception of virus strains Ashington and RCV, other recognised strains of Rabbit haemorrhagic disease virus (RHDV) share relatively close genetic homology. Using serology and phylogenetic analysis, we have identified a third disparate virus lineage in healthy rabbits on Lambay Island off the east coast of Eire, where disease due to RHDV has never been observed. ELISA tests revealed high titre RHDV-specific antibodies in 81% of the sera from 11 healthy rabbits captured on this island, indicating that the virus is actively circulating amongst these rabbits. Nevertheless, infectious virus has not been isolated from rabbits living on this island. The detection of antibodies and the disparate Lambay virus lineage in an apparently healthy and isolated wild rabbit population provides the most convincing evidence yet that at least some strains of RHDV can circulate harmlessly for long periods of time in wild rabbits possibly by producing persistent or latent infections.

Original language	English (US)
Pages (from-to)	18-22
Number of pages	5
Journal	Virology
Volume	358
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2006.09.011
State	Published - Feb 5 2007
Externally published	Yes

Keywords

Rabbit haemorrhagic disease virus

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2006.09.011

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title = "Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire",

abstract = "With the exception of virus strains Ashington and RCV, other recognised strains of Rabbit haemorrhagic disease virus (RHDV) share relatively close genetic homology. Using serology and phylogenetic analysis, we have identified a third disparate virus lineage in healthy rabbits on Lambay Island off the east coast of Eire, where disease due to RHDV has never been observed. ELISA tests revealed high titre RHDV-specific antibodies in 81% of the sera from 11 healthy rabbits captured on this island, indicating that the virus is actively circulating amongst these rabbits. Nevertheless, infectious virus has not been isolated from rabbits living on this island. The detection of antibodies and the disparate Lambay virus lineage in an apparently healthy and isolated wild rabbit population provides the most convincing evidence yet that at least some strains of RHDV can circulate harmlessly for long periods of time in wild rabbits possibly by producing persistent or latent infections.",

keywords = "Rabbit haemorrhagic disease virus",

author = "Forrester, {N. L.} and Trout, {R. C.} and Gould, {E. A.}",

note = "Funding Information: NLF was in receipt of an NERC studentship. This work was supported in part by the EU IP Project Vizier (CT 2004-511960). The authors wish to thank the anonymous reviewers for their helpful comments.",

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AU - Forrester, N. L.

AU - Trout, R. C.

AU - Gould, E. A.

N1 - Funding Information: NLF was in receipt of an NERC studentship. This work was supported in part by the EU IP Project Vizier (CT 2004-511960). The authors wish to thank the anonymous reviewers for their helpful comments.

PY - 2007/2/5

Y1 - 2007/2/5

N2 - With the exception of virus strains Ashington and RCV, other recognised strains of Rabbit haemorrhagic disease virus (RHDV) share relatively close genetic homology. Using serology and phylogenetic analysis, we have identified a third disparate virus lineage in healthy rabbits on Lambay Island off the east coast of Eire, where disease due to RHDV has never been observed. ELISA tests revealed high titre RHDV-specific antibodies in 81% of the sera from 11 healthy rabbits captured on this island, indicating that the virus is actively circulating amongst these rabbits. Nevertheless, infectious virus has not been isolated from rabbits living on this island. The detection of antibodies and the disparate Lambay virus lineage in an apparently healthy and isolated wild rabbit population provides the most convincing evidence yet that at least some strains of RHDV can circulate harmlessly for long periods of time in wild rabbits possibly by producing persistent or latent infections.

AB - With the exception of virus strains Ashington and RCV, other recognised strains of Rabbit haemorrhagic disease virus (RHDV) share relatively close genetic homology. Using serology and phylogenetic analysis, we have identified a third disparate virus lineage in healthy rabbits on Lambay Island off the east coast of Eire, where disease due to RHDV has never been observed. ELISA tests revealed high titre RHDV-specific antibodies in 81% of the sera from 11 healthy rabbits captured on this island, indicating that the virus is actively circulating amongst these rabbits. Nevertheless, infectious virus has not been isolated from rabbits living on this island. The detection of antibodies and the disparate Lambay virus lineage in an apparently healthy and isolated wild rabbit population provides the most convincing evidence yet that at least some strains of RHDV can circulate harmlessly for long periods of time in wild rabbits possibly by producing persistent or latent infections.

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Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire

Abstract

Keywords

ASJC Scopus subject areas

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