Bed rest and immunity

Gerald Sonnenfeld; Hernan Aviles; Janet S. Butel; William T. Shearer; David Niesel; Utpal Pandya; Christopher Allen; Hans D. Ochs; Antoine Blancher; Michel Abbal

doi:10.1016/j.actaastro.2006.08.004

Bed rest and immunity

Gerald Sonnenfeld, Hernan Aviles, Janet S. Butel, William T. Shearer, David Niesel, Utpal Pandya, Christopher Allen, Hans D. Ochs, Antoine Blancher, Michel Abbal

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.

Original language	English (US)
Pages (from-to)	234-236
Number of pages	3
Journal	Acta Astronautica
Volume	60
Issue number	4-7 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.actaastro.2006.08.004
State	Published - Feb 2007
Externally published	Yes

Keywords

Antibody responses
Bed rest
Blastogenesis
Cytokines
Viral reactivation

ASJC Scopus subject areas

Aerospace Engineering

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10.1016/j.actaastro.2006.08.004

Cite this

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title = "Bed rest and immunity",

abstract = "Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.",

keywords = "Antibody responses, Bed rest, Blastogenesis, Cytokines, Viral reactivation",

author = "Gerald Sonnenfeld and Hernan Aviles and Butel, {Janet S.} and Shearer, {William T.} and David Niesel and Utpal Pandya and Christopher Allen and Ochs, {Hans D.} and Antoine Blancher and Michel Abbal",

note = "Funding Information: The study WISE-2005 was sponsored by the European Space Agency (ESA), the National Aeronautics and Space Administration of the USA (NASA), the Canadian Space Agency (CSA), and the French “Centre National d{\textquoteright}Etudes Spatiales” CNES), which has been the “Promoteur” of the study according to French law. The study has been performed by MEDES, Institute for Space Physiology and Medicine in Toulouse, France. The National Aeronautics and Space Administration supported this work through NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute. ",

year = "2007",

month = feb,

doi = "10.1016/j.actaastro.2006.08.004",

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AU - Sonnenfeld, Gerald

AU - Aviles, Hernan

AU - Butel, Janet S.

AU - Shearer, William T.

AU - Niesel, David

AU - Pandya, Utpal

AU - Allen, Christopher

AU - Ochs, Hans D.

AU - Blancher, Antoine

AU - Abbal, Michel

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PY - 2007/2

Y1 - 2007/2

N2 - Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.

AB - Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.

KW - Antibody responses

KW - Bed rest

KW - Blastogenesis

KW - Cytokines

KW - Viral reactivation

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Bed rest and immunity

Abstract

Keywords

ASJC Scopus subject areas

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