Autophagy-lysosomal pathway as potential therapeutic target in Parkinson’s disease

Srinivasa Reddy Bonam, Christine Tranchant, Sylviane Muller

Research output: Contribution to journalReview articlepeer-review


Cellular quality control systems have gained much attention in recent decades. Among these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic cellular components and acts as an anti-ageing process. It is vital for cell survival and to preserve  homeostasis. Several cell-type-dependent canonical or non-canonical autophagy pathways have been reported showing varying degrees of selectivity with regard to the substrates targeted. Here, we provide an updated review of the autophagy machinery and discuss the role of various forms of autophagy in neurodegenerative diseases, with a particular focus on Parkinson’s disease. We describe recent findings that have led to the proposal of therapeutic strategies targeting autophagy to alter the course of Parkinson’s disease progression.

Original languageEnglish (US)
Article number3547
Issue number12
StatePublished - Dec 2021
Externally publishedYes


  • Autoimmunity
  • Autophagy
  • Lysosomes
  • Neurodegenerative disease
  • Parkinson’s disease

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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