TY - JOUR
T1 - ATP synthase subunit c storage in the polymorphonucleocytes of late infantile and juvenile batten patients
AU - Ansari, Naseem H.
AU - Cook, Jay D.
AU - Khanna, Peeyush
AU - Srivastava, Satish K.
PY - 1995/8
Y1 - 1995/8
N2 - In late infantile and juvenile forms of neuronal ceroid lipofuscinosis, commonly known as Batten disease (BD), ATP synthase subunit c accumulates in the lysosomes of neural cells. By using polyclonal antibodies, raised against bovine liver subunit c and an image analysis system for the quantification of antibody-linked alkaline phosphatase reaction, we have demonstrated that polymorphonucleocytes (PMN) from a late infantile and a juvenile BD patient stored several-fold more subunit c as compared to normal PMN.
AB - In late infantile and juvenile forms of neuronal ceroid lipofuscinosis, commonly known as Batten disease (BD), ATP synthase subunit c accumulates in the lysosomes of neural cells. By using polyclonal antibodies, raised against bovine liver subunit c and an image analysis system for the quantification of antibody-linked alkaline phosphatase reaction, we have demonstrated that polymorphonucleocytes (PMN) from a late infantile and a juvenile BD patient stored several-fold more subunit c as compared to normal PMN.
KW - ATP synthase subunit c
KW - Batten disease
KW - polymorphonucleocytes
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UR - http://www.scopus.com/inward/citedby.url?scp=0029160373&partnerID=8YFLogxK
U2 - 10.1016/0736-5748(95)00011-5
DO - 10.1016/0736-5748(95)00011-5
M3 - Article
C2 - 7484216
AN - SCOPUS:0029160373
SN - 0736-5748
VL - 13
SP - 455
EP - 462
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 5
ER -