Atopy, serum IgE, and interleukin-14 in steroid-responsive nephrotic syndrome

Wai Cheung, Chang Li Wei, Ching Ching Seah, Stanley C. Jordan, Hui Kim Yap

Research output: Contribution to journalArticlepeer-review


Earlier studies have demonstrated a strong association of steroid-responsive nephrotic syndrome (SRNS), atopy, and elevated serum IgE levels. Interleukin (IL-13) gene expression is significantly increased in children with SRNS in relapse. As interferon (IFN)-γ, IL-13, and IL-4 have regulatory effects on IgE synthesis, we examined the relationship between intracellular cytokine production and serum IgE levels in children with SRNS, in order to further define the reported association with atopy. The median serum IgE levels in nephrotic patients in relapse with (492 U/ml) or without atopy (561 U/ml) were significantly higher than those in remission (221 U/ml, P<0.002 or 90 U/ml, P< 0.001, respectively) and non-atopic controls (177 U/ml) (P<0.001). The percentage of CD3+ IL-13-producing cells was significantly higher in nephrotic children in relapse, and correlated with the serum IgE levels during the active phase of the disease (r=0.90, P<0.001). These data suggest that the elevated serum IgE levels during relapses of SRNS were the result of upregulation of IL-13. This probably reflects some common immune activation following various stimuli, rather than a direct association with atopy.

Original languageEnglish (US)
Pages (from-to)627-632
Number of pages6
JournalPediatric Nephrology
Issue number6
StatePublished - Jun 2004
Externally publishedYes


  • Atopy
  • Immunoglobulins
  • Steroid-responsive nephrotic syndrome
  • Th1/Th2 cytokine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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