Association of zoonotic Ljungan virus with intrauterine fetal deaths

Bo Niklasson; Annika Samsioe; Nikos Papadogiannakis; Anne Kawecki; Birger Hörnfeldt; George R. Saade; William Klitz

doi:10.1002/bdra.20359

Association of zoonotic Ljungan virus with intrauterine fetal deaths

Bo Niklasson, Annika Samsioe, Nikos Papadogiannakis, Anne Kawecki, Birger Hörnfeldt, George R. Saade, William Klitz

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

BACKGROUND: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse model. The question was therefore raised whether LV is a zoonotic agent in humans. METHODS: Population fluctuations of native rodents in Sweden were compared to the incidence of intrauterine fetal deaths (IUFDs) using the Swedish national hospitalization database. Formalin-fixed tissues from cases of IUFD were investigated using LV-specific immunohistochemistry. RESULTS: Variation in the incidence of IUFDs closely tracked the fluctuations in native rodent populations. LV was detected in the brain tissue in 4 of 10 cases of IUFDs investigated by immunochemistry. LV was also detected in the placenta in 5 of the 10 IUFD cases, but in none of 20 placentas from normal pregnancies. CONCLUSIONS: LV may play an important role in IUFDs.

Original language	English (US)
Pages (from-to)	488-493
Number of pages	6
Journal	Birth Defects Research Part A - Clinical and Molecular Teratology
Volume	79
Issue number	6
DOIs	https://doi.org/10.1002/bdra.20359
State	Published - Jun 2007

Keywords

Epidemiology
Immunohistochemistry
Infection
Intrauterine deaths
Ljungan virus
Zoonotic

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Embryology
Developmental Biology

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10.1002/bdra.20359

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title = "Association of zoonotic Ljungan virus with intrauterine fetal deaths",

abstract = "BACKGROUND: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse model. The question was therefore raised whether LV is a zoonotic agent in humans. METHODS: Population fluctuations of native rodents in Sweden were compared to the incidence of intrauterine fetal deaths (IUFDs) using the Swedish national hospitalization database. Formalin-fixed tissues from cases of IUFD were investigated using LV-specific immunohistochemistry. RESULTS: Variation in the incidence of IUFDs closely tracked the fluctuations in native rodent populations. LV was detected in the brain tissue in 4 of 10 cases of IUFDs investigated by immunochemistry. LV was also detected in the placenta in 5 of the 10 IUFD cases, but in none of 20 placentas from normal pregnancies. CONCLUSIONS: LV may play an important role in IUFDs.",

keywords = "Epidemiology, Immunohistochemistry, Infection, Intrauterine deaths, Ljungan virus, Zoonotic",

author = "Bo Niklasson and Annika Samsioe and Nikos Papadogiannakis and Anne Kawecki and Birger H{\"o}rnfeldt and Saade, {George R.} and William Klitz",

year = "2007",

month = jun,

doi = "10.1002/bdra.20359",

language = "English (US)",

volume = "79",

pages = "488--493",

journal = "Birth Defects Research Part A - Clinical and Molecular Teratology",

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AU - Niklasson, Bo

AU - Samsioe, Annika

AU - Papadogiannakis, Nikos

AU - Kawecki, Anne

AU - Hörnfeldt, Birger

AU - Saade, George R.

AU - Klitz, William

PY - 2007/6

Y1 - 2007/6

N2 - BACKGROUND: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse model. The question was therefore raised whether LV is a zoonotic agent in humans. METHODS: Population fluctuations of native rodents in Sweden were compared to the incidence of intrauterine fetal deaths (IUFDs) using the Swedish national hospitalization database. Formalin-fixed tissues from cases of IUFD were investigated using LV-specific immunohistochemistry. RESULTS: Variation in the incidence of IUFDs closely tracked the fluctuations in native rodent populations. LV was detected in the brain tissue in 4 of 10 cases of IUFDs investigated by immunochemistry. LV was also detected in the placenta in 5 of the 10 IUFD cases, but in none of 20 placentas from normal pregnancies. CONCLUSIONS: LV may play an important role in IUFDs.

AB - BACKGROUND: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse model. The question was therefore raised whether LV is a zoonotic agent in humans. METHODS: Population fluctuations of native rodents in Sweden were compared to the incidence of intrauterine fetal deaths (IUFDs) using the Swedish national hospitalization database. Formalin-fixed tissues from cases of IUFD were investigated using LV-specific immunohistochemistry. RESULTS: Variation in the incidence of IUFDs closely tracked the fluctuations in native rodent populations. LV was detected in the brain tissue in 4 of 10 cases of IUFDs investigated by immunochemistry. LV was also detected in the placenta in 5 of the 10 IUFD cases, but in none of 20 placentas from normal pregnancies. CONCLUSIONS: LV may play an important role in IUFDs.

KW - Epidemiology

KW - Immunohistochemistry

KW - Infection

KW - Intrauterine deaths

KW - Ljungan virus

KW - Zoonotic

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Association of zoonotic Ljungan virus with intrauterine fetal deaths

Abstract

Keywords

ASJC Scopus subject areas

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