Abstract
Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.
Original language | English (US) |
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Pages (from-to) | 1352-1361 |
Number of pages | 10 |
Journal | Journal of Infectious Diseases |
Volume | 215 |
Issue number | 9 |
DOIs | |
State | Published - May 1 2017 |
Externally published | Yes |
Keywords
- atherosclerosis
- galectin-3
- galectin-3 binding protein
- HIV infection
- inflammation
- intima-media thickness
- macrophages
- monocytes
- soluble CD14
- soluble CD163
ASJC Scopus subject areas
- General Medicine