Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling

Gracie Vargas, Jennifer Kehlet Barton, Bernard Choi, Joseph A. Izatt, Ashley J. Welch

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


The effects of cooling, laser irradiation, and laser irradiation with cooling on blood vessels were investigated with Color Doppler Optical Coherence Tomography (CDOCT). CDOCT may contribute to an understanding of the dynamics of laser-blood vessel interactions and aid in better optimization of laser parameters to be used. In this study, hamster dorsal skin flap window vessels were irradiated with a KTP laser operating at 532 nm. Irradiation sites were imaged with CDOCT prior to, during, immediately after, and several days after irradiation. KTP laser parameters were: radiant exposures in the range of 7-14 J/cm2, 3 mm spot size, and 10 ms pulse duration. Magnitude and color Doppler images provided information such as vessel size, depth, and changes in blood flow velocity. Vessel constriction, temporary occlusion, and changes in flow were frequent results of laser irradiation visualized with CDOCT. In addition, the effects of cooling alone were imaged with CDOCT and its effects on blood vessel flow and morphology were investigated before and after laser irradiation.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III - San Jose, CA, USA
Duration: Jan 27 1999Jan 29 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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