Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway

Demidmaa Tuvdendorj, Makoto Oketani, Ryuji Ikeda, Kazunori Kohara, Yasuzi Komorizono, Kazuaki Ishibashi, Namid Munkhtuvshin, Terukatsu Arima

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Here we studied whether aspirin (ASA) has any influence on viability of human hepatoma-derived SKHep-1 cells and whether hydrogen peroxide (H2O2) has any relation with this effect. ASA inhibited SKHep-1 cell proliferation dose- and time-dependently. Intracellular H2O2 increased as early as 15 min after ASA supplementation. Cellular apoptosis correlated with an increase in intracellular H2O2 level. Moreover, in the presence of a catalase inhibitor-aminotriazol, ASA showed more apoptotic effect on SKHep-1 cells with increasing intracellular H2O2 level. In conclusion, the present results shows that ASA induced SKHep-1 cell apoptosis has a relation with an early increase in intracellular H2O2 level and catalase inhibitor synergizes to induce this process.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalHepatology Research
Issue number1
StatePublished - May 1 2003
Externally publishedYes


  • Acetylsalicylic acid
  • Aminotriazol
  • Hepatocellular carcinoma
  • Hydrogen peroxide
  • SKHep-1

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases


Dive into the research topics of 'Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway'. Together they form a unique fingerprint.

Cite this