TY - JOUR
T1 - Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines
AU - Reynolds, C. Patrick
AU - Perez-Polo, J. Regino
N1 - Funding Information:
Supported by NINCDS Grants NS15324, NS14034, and RCDA NS00213 to J.R.P-P. Thanks to B. Dzambo for manuscript preparation.
PY - 1981/10/23
Y1 - 1981/10/23
N2 - Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.
AB - Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.
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U2 - 10.1016/0304-3940(81)90341-4
DO - 10.1016/0304-3940(81)90341-4
M3 - Article
C2 - 6795547
AN - SCOPUS:0019813684
SN - 0304-3940
VL - 26
SP - 151
EP - 155
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -