Asbestos and DNA double strand breaks

Ryuichi Okayasu, Sentaro Takahashi, Shigeru Yamada, Tom K. Hei, Robert L. Ullrich

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short- term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.

Original languageEnglish (US)
Pages (from-to)298-300
Number of pages3
JournalCancer Research
Issue number2
StatePublished - Jan 16 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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