Asbestos and DNA double strand breaks

Ryuichi Okayasu; Sentaro Takahashi; Shigeru Yamada; Tom K. Hei; Robert L. Ullrich

Asbestos and DNA double strand breaks

Ryuichi Okayasu, Sentaro Takahashi, Shigeru Yamada, Tom K. Hei, Robert L. Ullrich

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short- term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.

Original language	English (US)
Pages (from-to)	298-300
Number of pages	3
Journal	Cancer Research
Volume	59
Issue number	2
State	Published - Jan 16 1999

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Asbestos and DNA double strand breaks",

abstract = "A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short- term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.",

author = "Ryuichi Okayasu and Sentaro Takahashi and Shigeru Yamada and Hei, {Tom K.} and Ullrich, {Robert L.}",

year = "1999",

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AU - Okayasu, Ryuichi

AU - Takahashi, Sentaro

AU - Yamada, Shigeru

AU - Hei, Tom K.

AU - Ullrich, Robert L.

PY - 1999/1/16

Y1 - 1999/1/16

N2 - A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short- term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.

AB - A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short- term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.

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M3 - Article

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SN - 0008-5472

VL - 59

SP - 298

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JO - Cancer Research

JF - Cancer Research

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ER -

Asbestos and DNA double strand breaks

Abstract

ASJC Scopus subject areas

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