Artificial Scaffolds in Cardiac Tissue Engineering

Jorge A. Roacho-Pérez, Elsa N. Garza-Treviño, Nidia K. Moncada-Saucedo, Pablo A. Carriquiry-Chequer, Laura E. Valencia-Gómez, Elizabeth Renee Matthews, Víctor Gómez-Flores, Mario Simental-Mendía, Paulina Delgado-Gonzalez, Juan Luis Delgado-Gallegos, Gerardo R. Padilla-Rivas, Jose Francisco Islas

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiovascular diseases are a leading cause of death worldwide. Current treatments directed at heart repair have several disadvantages, such as a lack of donors for heart transplantation or non-bioactive inert materials for replacing damaged tissue. Because of the natural lack of regeneration of cardiomyocytes, new treatment strategies involve stimulating heart tissue regeneration. The basic three elements of cardiac tissue engineering (cells, growth factors, and scaffolds) are described in this review, with a highlight on the role of artificial scaffolds. Scaffolds for cardiac tissue engineering are tridimensional porous structures that imitate the extracellular heart matrix, with the ability to promote cell adhesion, migration, differentiation, and proliferation. In the heart, there is an important requirement to provide scaffold cellular attachment, but scaffolds also need to permit mechanical contractility and electrical conductivity. For researchers working in cardiac tissue engineering, there is an important need to choose an adequate artificial scaffold biofabrication technique, as well as the ideal biocompatible biodegradable biomaterial for scaffold construction. Finally, there are many suitable options for researchers to obtain scaffolds that promote cell–electrical interactions and tissue repair, reaching the goal of cardiac tissue engineering.

Original languageEnglish (US)
Article number1117
JournalLife
Volume12
Issue number8
DOIs
StatePublished - Aug 2022
Externally publishedYes

Keywords

  • artificial scaffolds
  • biomaterials
  • cardiac tissue engineering
  • cardiovascular diseases

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • General Biochemistry, Genetics and Molecular Biology
  • Space and Planetary Science
  • Palaeontology

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