Arthritis syndromes associated with human T cell lymphotropic virus type I infection

R. M. McCallum, D. D. Patel, J. O. Moore, B. F. Haynes

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalMedical Clinics of North America
Issue number1
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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