Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus

Jason T. Kaelber, Wen Jiang, Scott C. Weaver, Albert Auguste, Wah Chiu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The arrangement of polymerases inside an unusual nine-segmented dsRNA virus was determined by Kaelber et al. While cryo-EM is typically used to average copies of a protein into one structure, they also compared raw images with synthetic maps to test whether subsets of virions had different arrangements.

Original languageEnglish (US)
Pages (from-to)604-612.e3
Issue number6
StatePublished - Jun 2 2020
Externally publishedYes


  • RNA-dependent RNA polymerase
  • Reoviridae
  • asymmetric reconstruction
  • cryo-EM reconstruction
  • single particle

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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