Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Xianbin Yang; Susan Fennewald; Bruce A. Luxon; Judy Aronson; Norbert K. Herzog; David G. Gorenstein

doi:10.1016/S0960-894X(99)00600-9

Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Xianbin Yang, Susan Fennewald, Bruce A. Luxon, Judy Aronson, Norbert K. Herzog, David G. Gorenstein

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

Original language	English (US)
Pages (from-to)	3357-3362
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(99)00600-9
State	Published - Dec 6 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(99)00600-9

Cite this

@article{817576242edd4c709d509dba148d6253,

title = "Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB",

abstract = "Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.",

author = "Xianbin Yang and Susan Fennewald and Luxon, {Bruce A.} and Judy Aronson and Herzog, {Norbert K.} and Gorenstein, {David G.}",

year = "1999",

month = dec,

day = "6",

doi = "10.1016/S0960-894X(99)00600-9",

language = "English (US)",

volume = "9",

pages = "3357--3362",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "23",

}

TY - JOUR

T1 - Aptamers containing thymidine 3'-O-phosphorodithioates

T2 - Synthesis and binding to nuclear factor-κB

AU - Yang, Xianbin

AU - Fennewald, Susan

AU - Luxon, Bruce A.

AU - Aronson, Judy

AU - Herzog, Norbert K.

AU - Gorenstein, David G.

PY - 1999/12/6

Y1 - 1999/12/6

N2 - Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

AB - Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

UR - http://www.scopus.com/inward/record.url?scp=0033530825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033530825&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(99)00600-9

DO - 10.1016/S0960-894X(99)00600-9

M3 - Article

C2 - 10612599

AN - SCOPUS:0033530825

SN - 0960-894X

VL - 9

SP - 3357

EP - 3362

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this