AP-2 makes room for rivals

Sanja Sever

doi:10.1016/S1534-5807(03)00304-6

AP-2 makes room for rivals

Research output: Contribution to journal › Review article › peer-review

Abstract

Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

Original language	English (US)
Pages (from-to)	530-532
Number of pages	3
Journal	Developmental cell
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/S1534-5807(03)00304-6
State	Published - Oct 1 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.1016/S1534-5807(03)00304-6

Cite this

@article{ee653a18028145e4af1b5e6b15e2717a,

title = "AP-2 makes room for rivals",

abstract = "Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.",

author = "Sanja Sever",

year = "2003",

month = oct,

day = "1",

doi = "10.1016/S1534-5807(03)00304-6",

language = "English (US)",

volume = "5",

pages = "530--532",

journal = "Developmental cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - AP-2 makes room for rivals

AU - Sever, Sanja

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

AB - Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

UR - http://www.scopus.com/inward/record.url?scp=0141920733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141920733&partnerID=8YFLogxK

U2 - 10.1016/S1534-5807(03)00304-6

DO - 10.1016/S1534-5807(03)00304-6

M3 - Review article

C2 - 14536052

AN - SCOPUS:0141920733

SN - 1534-5807

VL - 5

SP - 530

EP - 532

JO - Developmental cell

JF - Developmental cell

IS - 4

ER -

AP-2 makes room for rivals

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this