Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Jang Gi Choi; Ji Young Choi; Su Hyun Mun; Ok Hwa Kang; Preeti Bharaj; Dong Won Shin; Myong Soo Chong; Dong Yeul Kwon

doi:10.1016/j.apjtm.2015.06.010

Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Jang Gi Choi, Ji Young Choi, Su Hyun Mun, Ok Hwa Kang, Preeti Bharaj, Dong Won Shin, Myong Soo Chong, Dong Yeul Kwon

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

Original language	English (US)
Pages (from-to)	538-542
Number of pages	5
Journal	Asian Pacific Journal of Tropical Medicine
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/j.apjtm.2015.06.010
State	Published - Jul 1 2015
Externally published	Yes

Keywords

Ciprofloxacin
Methicillin-resistant Staphylococcus aureus
Sami-Hyanglyun-Hwan
Synergy

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/j.apjtm.2015.06.010

Cite this

@article{b6a3bb80daf34ab9a165565f6a6464c9,

title = "Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus",

abstract = "Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.",

keywords = "Ciprofloxacin, Methicillin-resistant Staphylococcus aureus, Sami-Hyanglyun-Hwan, Synergy",

author = "Choi, {Jang Gi} and Choi, {Ji Young} and Mun, {Su Hyun} and Kang, {Ok Hwa} and Preeti Bharaj and Shin, {Dong Won} and Chong, {Myong Soo} and Kwon, {Dong Yeul}",

note = "Publisher Copyright: {\textcopyright} 2015 Hainan Medical College.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.apjtm.2015.06.010",

language = "English (US)",

volume = "8",

pages = "538--542",

journal = "Asian Pacific Journal of Tropical Medicine",

issn = "1995-7645",

publisher = "Wolters Kluwer Medknow Publications",

number = "7",

}

TY - JOUR

T1 - Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

AU - Choi, Jang Gi

AU - Choi, Ji Young

AU - Mun, Su Hyun

AU - Kang, Ok Hwa

AU - Bharaj, Preeti

AU - Shin, Dong Won

AU - Chong, Myong Soo

AU - Kwon, Dong Yeul

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

AB - Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

KW - Ciprofloxacin

KW - Methicillin-resistant Staphylococcus aureus

KW - Sami-Hyanglyun-Hwan

KW - Synergy

UR - http://www.scopus.com/inward/record.url?scp=84938956804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938956804&partnerID=8YFLogxK

U2 - 10.1016/j.apjtm.2015.06.010

DO - 10.1016/j.apjtm.2015.06.010

M3 - Article

AN - SCOPUS:84938956804

SN - 1995-7645

VL - 8

SP - 538

EP - 542

JO - Asian Pacific Journal of Tropical Medicine

JF - Asian Pacific Journal of Tropical Medicine

IS - 7

ER -

Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this