Anti-CCR5 antibodies in sera of HIV-positive individuals

Edith Grene; Ligia A. Pinto; Alan L. Landay; Harold A. Kessler; Stephanie A. Anderson; Matthew J. Dolan; Gene M. Shearer

doi:10.1016/S0198-8859(00)00243-3

Anti-CCR5 antibodies in sera of HIV-positive individuals

Edith Grene, Ligia A. Pinto, Alan L. Landay, Harold A. Kessler, Stephanie A. Anderson, Matthew J. Dolan, Gene M. Shearer

Research output: Contribution to journal › Article › peer-review

Abstract

One of the proposed mechanisms for resistance to human immunodeficiency virus-1 (HIV-1) infection is the presence of antibodies against receptor for CC-chemokines (CCR5). These antibodies, detected in sera of uninfected individuals exposed to HIV, have been shown to downmodulate surface CCR5 in vivo and are able to neutralize the infectivity of CCR5 strains in vitro. To address the potential role of anti-CCR5 antibodies in HIV infection, we analyzed anti-CCR5 antibody levels in plasma from HIV-infected patients who present a wide range of CD4⁺ T-cell counts and viral load. Increased levels of anti-CCR5 antibodies were found in plasma from 13/46 HIV-positive donors compared with healthy controls (0/36). However, antibody levels were not associated with disease stage evaluated by CD4⁺ T-cell counts and viral load.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Human Immunology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/S0198-8859(00)00243-3
State	Published - 2001
Externally published	Yes

Keywords

CCR5
Chemokines
HIV infection

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0198-8859(00)00243-3

Cite this

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title = "Anti-CCR5 antibodies in sera of HIV-positive individuals",

abstract = "One of the proposed mechanisms for resistance to human immunodeficiency virus-1 (HIV-1) infection is the presence of antibodies against receptor for CC-chemokines (CCR5). These antibodies, detected in sera of uninfected individuals exposed to HIV, have been shown to downmodulate surface CCR5 in vivo and are able to neutralize the infectivity of CCR5 strains in vitro. To address the potential role of anti-CCR5 antibodies in HIV infection, we analyzed anti-CCR5 antibody levels in plasma from HIV-infected patients who present a wide range of CD4+ T-cell counts and viral load. Increased levels of anti-CCR5 antibodies were found in plasma from 13/46 HIV-positive donors compared with healthy controls (0/36). However, antibody levels were not associated with disease stage evaluated by CD4+ T-cell counts and viral load.",

keywords = "CCR5, Chemokines, HIV infection",

author = "Edith Grene and Pinto, {Ligia A.} and Landay, {Alan L.} and Kessler, {Harold A.} and Anderson, {Stephanie A.} and Dolan, {Matthew J.} and Shearer, {Gene M.}",

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doi = "10.1016/S0198-8859(00)00243-3",

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AU - Grene, Edith

AU - Pinto, Ligia A.

AU - Landay, Alan L.

AU - Kessler, Harold A.

AU - Anderson, Stephanie A.

AU - Dolan, Matthew J.

AU - Shearer, Gene M.

PY - 2001

Y1 - 2001

N2 - One of the proposed mechanisms for resistance to human immunodeficiency virus-1 (HIV-1) infection is the presence of antibodies against receptor for CC-chemokines (CCR5). These antibodies, detected in sera of uninfected individuals exposed to HIV, have been shown to downmodulate surface CCR5 in vivo and are able to neutralize the infectivity of CCR5 strains in vitro. To address the potential role of anti-CCR5 antibodies in HIV infection, we analyzed anti-CCR5 antibody levels in plasma from HIV-infected patients who present a wide range of CD4+ T-cell counts and viral load. Increased levels of anti-CCR5 antibodies were found in plasma from 13/46 HIV-positive donors compared with healthy controls (0/36). However, antibody levels were not associated with disease stage evaluated by CD4+ T-cell counts and viral load.

AB - One of the proposed mechanisms for resistance to human immunodeficiency virus-1 (HIV-1) infection is the presence of antibodies against receptor for CC-chemokines (CCR5). These antibodies, detected in sera of uninfected individuals exposed to HIV, have been shown to downmodulate surface CCR5 in vivo and are able to neutralize the infectivity of CCR5 strains in vitro. To address the potential role of anti-CCR5 antibodies in HIV infection, we analyzed anti-CCR5 antibody levels in plasma from HIV-infected patients who present a wide range of CD4+ T-cell counts and viral load. Increased levels of anti-CCR5 antibodies were found in plasma from 13/46 HIV-positive donors compared with healthy controls (0/36). However, antibody levels were not associated with disease stage evaluated by CD4+ T-cell counts and viral load.

KW - CCR5

KW - Chemokines

KW - HIV infection

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Anti-CCR5 antibodies in sera of HIV-positive individuals

Abstract

Keywords

ASJC Scopus subject areas

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