Antenatal factors associated with significant birth weight discordancy in twin gestations

Víctor H. González-Quintero, Barbara Luke, Mary J. O'Sullivan, Ruta Misiunas, Elaine Anderson, Clark Nugent, Frank Witter, Jill Mauldin, Roger Newman, Mary D'Alton, David Grainger, George Saade, Gary Hankins, George Macones

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


OBJECTIVE: The purpose of this study was to evaluate factors that are associated with significant birth weight discordancy. STUDY DESIGN: As a part of an ongoing collaborative study of twins, maternal and fetal data were obtained from the medical records of twin gestations at eight medical centers. The study population was divided into groups by difference in birth weight discordancy (≥20%, ≥25%, and ≥30%) RESULTS: Severe birth weight discordancy was associated with fetal growth deceleration by 20 to 28 weeks (adjusted odds ratio, 4.90; 95% CI, 3.15-7.64) and between 28 weeks to birth (adjusted odds ratio, 3.48; 95% CI, 1.72-7.06). Antenatal bleeding (adjusted odds ratio, 1.86; 95% CI, 1.08-3.21), preeclampsia (adjusted odds ratio, 1.70, 95% CI, 1.21-2.41), and monochorionicity (adjusted odds ratio, 2.35, 95% CI, 11.71-3.23) were also associated with birth weight discordancy. CONCLUSION: These data demonstrate the importance of the early diagnosis of placental chorionicity, because monochorionicity is associated with a 2-fold increase in birth weight discordancy in twin gestations.

Original languageEnglish (US)
Pages (from-to)813-817
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number3
StatePublished - Sep 1 2003


  • Birth weight discordancy
  • Monochorionicity
  • Twin gestation

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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