Anomalous diffusion of DNA on a supported cationic lipid membrane

Chen Ming Chang, Yuk Gyn Lau, Shu Ching Ou, Tse Yu Lin, Wen Tau Juan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.

Original languageEnglish (US)
Article number38002
Issue number3
StatePublished - Feb 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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