TY - JOUR
T1 - Androgen treatment and muscle strength in elderly men
T2 - A meta-analysis
AU - Ottenbacher, Kenneth J.
AU - Ottenbacher, Margaret E.
AU - Ottenbacher, Allison J.
AU - Acha, Ana Alfaro
AU - Ostir, Glenn V.
PY - 2006/11
Y1 - 2006/11
N2 - OBJECTIVES: To review published, randomized trials examining the effect of androgen treatment on muscle strength in older men. DESIGN: Systematic review using meta-analysis procedures. SETTING: Computerized and manual searches. PARTICIPANTS: MEDLINE, EMBASE, CINAHL, and the Cochrane Register were searched for trials. Key words included testosterone, androgen, sarcopenia, muscle loss, aged, aging, elderly, older, geriatric, randomized controlled trials, and controlled clinical trials. Sixty-five nonoverlapping studies were found. Meta-analysis methods were used to evaluate the 11 randomized, double-blind trials. INTERVENTION: Testosterone or dihydrotestosterone (DHT) replacement therapy in healthy men aged 65 and older. MEASUREMENTS: Tests of muscle strength. RESULTS: The studies included 38 statistical comparisons. The mean g-index (gi) adjusted for sample size was 0.53 (95% confidence interval (CI)=0.21-0.86). Subanalyses revealed larger effects for measures of lower extremity muscle strength (gi=0.63, 95% CI=0.03-1.28) than for upper extremity muscle strength (gi=0.47, 95% CI=0.12-0.84). A larger mean g-index was found for injected (gi=0.95, 95% CI=0.33-1.58) than topical (gi=0.26, 95% CI=0.08-0.42) or oral (gi=-0.21, 95% CI=-1.40-1.02) administration of testosterone/DHT. Effect sizes were related to study characteristics such as subject attrition and design-quality ratings. Sensitivity analyses revealed that the elimination of one study reduced the mean g-index from 0.53 to 0.23. CONCLUSION: The results suggest that testosterone/DHT therapy produced a moderate increase in muscle strength in men participating in 11 randomized trials. One study influenced the mean effect size.
AB - OBJECTIVES: To review published, randomized trials examining the effect of androgen treatment on muscle strength in older men. DESIGN: Systematic review using meta-analysis procedures. SETTING: Computerized and manual searches. PARTICIPANTS: MEDLINE, EMBASE, CINAHL, and the Cochrane Register were searched for trials. Key words included testosterone, androgen, sarcopenia, muscle loss, aged, aging, elderly, older, geriatric, randomized controlled trials, and controlled clinical trials. Sixty-five nonoverlapping studies were found. Meta-analysis methods were used to evaluate the 11 randomized, double-blind trials. INTERVENTION: Testosterone or dihydrotestosterone (DHT) replacement therapy in healthy men aged 65 and older. MEASUREMENTS: Tests of muscle strength. RESULTS: The studies included 38 statistical comparisons. The mean g-index (gi) adjusted for sample size was 0.53 (95% confidence interval (CI)=0.21-0.86). Subanalyses revealed larger effects for measures of lower extremity muscle strength (gi=0.63, 95% CI=0.03-1.28) than for upper extremity muscle strength (gi=0.47, 95% CI=0.12-0.84). A larger mean g-index was found for injected (gi=0.95, 95% CI=0.33-1.58) than topical (gi=0.26, 95% CI=0.08-0.42) or oral (gi=-0.21, 95% CI=-1.40-1.02) administration of testosterone/DHT. Effect sizes were related to study characteristics such as subject attrition and design-quality ratings. Sensitivity analyses revealed that the elimination of one study reduced the mean g-index from 0.53 to 0.23. CONCLUSION: The results suggest that testosterone/DHT therapy produced a moderate increase in muscle strength in men participating in 11 randomized trials. One study influenced the mean effect size.
KW - Evaluation
KW - Exercise
KW - Hormone
KW - Testosterone
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U2 - 10.1111/j.1532-5415.2006.00938.x
DO - 10.1111/j.1532-5415.2006.00938.x
M3 - Article
C2 - 17087692
AN - SCOPUS:33750518404
SN - 0002-8614
VL - 54
SP - 1666
EP - 1673
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 11
ER -