Analyzing the cryptome: Uncovering secret sequences

Parimal Samir, Andrew J. Link

Research output: Contribution to journalReview articlepeer-review


The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalAAPS Journal
Issue number2
StatePublished - Jun 2011
Externally publishedYes


  • bioactive peptides
  • cryptides
  • cryptome
  • cryptomics
  • mass spectrometry-based proteomics

ASJC Scopus subject areas

  • Pharmaceutical Science


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