Analysis of Golgi Secretory Functions in Cancer

Priyam Banerjee, Xiaochao Tan, William K. Russell, Jonathan M. Kurie

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer cells utilize secretory pathways for paracrine signaling and extracellular matrix remodeling to facilitate directional cell migration, invasion, and metastasis. The Golgi apparatus is a central secretory signaling hub that is often deregulated in cancer. Here we described technologies that utilize microscopic, biochemical, and proteomic approaches to analyze Golgi secretory functions in genetically heterogeneous cancer cell lines.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages785-810
Number of pages26
DOIs
StatePublished - 2023
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2557
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Cancer
  • Confocal microscopy
  • Golgi apparatus
  • Live-cell imaging
  • Proteomics
  • Quantitative image analysis
  • Secretion
  • Subcellular fractionation
  • Vesicle trafficking

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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