@article{c7f8f623e69d4dd0b2e91ad23e204659,
title = "Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization",
abstract = "Cooperative interactions of monoclonal antibodies (mAbs) with viral antigens are poorly understood. Gilchuk et al. perform structural and functional analysis of cooperativity in a cocktail of two human mAbs, recognizing major epitopes of ebolavirus glycoprotein (GP), and define cooperative binding of the GP as a mechanism for enhanced ebolavirus neutralization.",
keywords = "Ebolavirus, antibody synergy, antibody therapeutics, cooperative neutralization, ebolavirus infection, epitope mapping, glycoprotein, molecular mimicry, neutralizing antibodies, viral antibodies",
author = "Pavlo Gilchuk and Murin, {Charles D.} and Milligan, {Jacob C.} and Cross, {Robert W.} and Mire, {Chad E.} and Ilinykh, {Philipp A.} and Kai Huang and Natalia Kuzmina and Altman, {Pilar X.} and Sean Hui and Gunn, {Bronwyn M.} and Bryan, {Aubrey L.} and Edgar Davidson and Doranz, {Benjamin J.} and Turner, {Hannah L.} and Tanwee Alkutkar and Robin Flinko and Chiara Orlandi and Robert Carnahan and Rachel Nargi and Bombardi, {Robin G.} and Vodzak, {Megan E.} and Sheng Li and Adaora Okoli and Morris Ibeawuchi and Benjamin Ohiaeri and Lewis, {George K.} and Galit Alter and Alexander Bukreyev and Saphire, {Erica Ollmann} and Geisbert, {Thomas W.} and Ward, {Andrew B.} and Crowe, {James E.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = feb,
day = "18",
doi = "10.1016/j.immuni.2020.01.001",
language = "English (US)",
volume = "52",
pages = "388--403.e12",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",
}