An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Elshad Hasanov, Debra Nana Yeboa, Mathew D. Tucker, Todd A. Swanson, Thomas Hendrix Beckham, Brian Rini, Chibawanye I. Ene, Merve Hasanov, Sophie Derks, Marion Smits, Shaan Dudani, Daniel Y.C. Heng, Priscilla K. Brastianos, Axel Bex, Sahin Hanalioglu, Jeffrey S. Weinberg, Laure Hirsch, Maria I. Carlo, Ayal Aizer, Paul David BrownMehmet Asim Bilen, Eric Lin Chang, Jerry Jaboin, James Brugarolas, Toni K. Choueiri, Michael B. Atkins, Bradley A. McGregor, Lia M. Halasz, Toral R. Patel, Scott G. Soltys, David F. McDermott, James Bradley Elder, Mustafa K. Baskaya, James B. Yu, Robert Timmerman, Michelle Miran Kim, Melike Mut, James Markert, Kathryn Beal, Nizar M. Tannir, George Samandouras, Frederick F. Lang, Rachel Giles, Eric Jonasch

Research output: Contribution to journalReview articlepeer-review


Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.

Original languageEnglish (US)
Pages (from-to)454-489
Number of pages36
JournalCA Cancer Journal for Clinicians
Issue number5
StatePublished - Sep 1 2022
Externally publishedYes


  • brain metastases
  • diagnostic evaluation
  • immune checkpoint blockers
  • renal cell carcinoma

ASJC Scopus subject areas

  • Hematology
  • Oncology


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