TY - JOUR
T1 - An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research
AU - Gracie, Sara
AU - Pennell, Craig
AU - Ekman-Ordeberg, Gunvor
AU - Lye, Stephen
AU - McManaman, James
AU - Williams, Scott
AU - Palmer, Lyle
AU - Kelley, Maureen
AU - Menon, Ram
AU - Gravett, Michael
PY - 2011/10/12
Y1 - 2011/10/12
N2 - Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multi-factorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.
AB - Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multi-factorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.
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U2 - 10.1186/1471-2393-11-71
DO - 10.1186/1471-2393-11-71
M3 - Letter
C2 - 21992798
AN - SCOPUS:80053905126
SN - 1471-2393
VL - 11
JO - BMC Pregnancy and Childbirth
JF - BMC Pregnancy and Childbirth
M1 - 71
ER -