An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Xiao Shuang Zhang, Yan Liu, Li Zhao, Bing Li, Hao Yu, Hong Ling Wen, Xue Jie Yu

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are potential amplifying hosts of SFTSV. The clinical symptoms of SFTS are nonspecific, but major symptoms include fever, gastrointestinal symptoms, myalgia, dizziness, joint pain, chills, and regional lymphadenopathy. The most common abnormalities in laboratory test results are thrombocytopenia (95%), leukocytopenia (86%), and elevated levels of serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase. The fatality rate for SFTS is 12% on average, and the annual incidence of the disease is approximately five per 100000 of the rural population.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalScience China Life Sciences
Issue number8
StatePublished - Aug 2013


  • Phlebovirus
  • bunyavirus
  • emerging infectious diseases
  • hemorrhagic fever
  • leukopenia
  • thrombocytopenia
  • tick

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Environmental Science
  • General Agricultural and Biological Sciences


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