Amyrisins A-C, O -prenylated flavonoids from amyris madrensis

Jiangnan Peng; Rachel M. Hartley; Gary A. Fest; Susan L. Mooberry

doi:10.1021/np200796e

Amyrisins A-C, O -prenylated flavonoids from amyris madrensis

Jiangnan Peng, Rachel M. Hartley, Gary A. Fest, Susan L. Mooberry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC ₅₀ values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.

Original language	English (US)
Pages (from-to)	494-496
Number of pages	3
Journal	Journal of Natural Products
Volume	75
Issue number	3
DOIs	https://doi.org/10.1021/np200796e
State	Published - Mar 23 2012
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC 50 values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.",

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AU - Peng, Jiangnan

AU - Hartley, Rachel M.

AU - Fest, Gary A.

AU - Mooberry, Susan L.

PY - 2012/3/23

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AB - Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC 50 values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.

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Amyrisins A-C, O -prenylated flavonoids from amyris madrensis

Abstract

ASJC Scopus subject areas

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