Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat

Ella W. Englander; Guillermo A. Gomez; George H. Greeley

doi:10.1016/j.mad.2004.06.011

Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat

Ella W. Englander, Guillermo A. Gomez, George H. Greeley

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Ghrelin is a recently discovered stomach hormone that stimulates growth hormone (GH) secretion, food intake, adiposity, and growth. In this report, we present new and previously published data from our laboratory showing that stomach ghrelin production and secretion are increased, and that GH release in response to exogenous ghrelin is enhanced in the aged rat. Together, these data suggest that the aging associated decline in GH secretion is not due to a reduction in stomach ghrelin secretion or a stimulatory action on GH release.

Original language	English (US)
Pages (from-to)	871-875
Number of pages	5
Journal	Mechanisms of Ageing and Development
Volume	125
Issue number	12 SPEC.ISS.
DOIs	https://doi.org/10.1016/j.mad.2004.06.011
State	Published - Dec 2004

Keywords

Aging
Ghrelin
Growth hormone
Secretion
Stomach

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/j.mad.2004.06.011

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title = "Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat",

abstract = "Ghrelin is a recently discovered stomach hormone that stimulates growth hormone (GH) secretion, food intake, adiposity, and growth. In this report, we present new and previously published data from our laboratory showing that stomach ghrelin production and secretion are increased, and that GH release in response to exogenous ghrelin is enhanced in the aged rat. Together, these data suggest that the aging associated decline in GH secretion is not due to a reduction in stomach ghrelin secretion or a stimulatory action on GH release.",

keywords = "Aging, Ghrelin, Growth hormone, Secretion, Stomach",

author = "Englander, {Ella W.} and Gomez, {Guillermo A.} and Greeley, {George H.}",

note = "Funding Information: This work is supported by the National Institutes of Health Grants RO1 DK61614 and AG 23149.",

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T1 - Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat

AU - Englander, Ella W.

AU - Gomez, Guillermo A.

AU - Greeley, George H.

N1 - Funding Information: This work is supported by the National Institutes of Health Grants RO1 DK61614 and AG 23149.

PY - 2004/12

Y1 - 2004/12

N2 - Ghrelin is a recently discovered stomach hormone that stimulates growth hormone (GH) secretion, food intake, adiposity, and growth. In this report, we present new and previously published data from our laboratory showing that stomach ghrelin production and secretion are increased, and that GH release in response to exogenous ghrelin is enhanced in the aged rat. Together, these data suggest that the aging associated decline in GH secretion is not due to a reduction in stomach ghrelin secretion or a stimulatory action on GH release.

AB - Ghrelin is a recently discovered stomach hormone that stimulates growth hormone (GH) secretion, food intake, adiposity, and growth. In this report, we present new and previously published data from our laboratory showing that stomach ghrelin production and secretion are increased, and that GH release in response to exogenous ghrelin is enhanced in the aged rat. Together, these data suggest that the aging associated decline in GH secretion is not due to a reduction in stomach ghrelin secretion or a stimulatory action on GH release.

KW - Aging

KW - Ghrelin

KW - Growth hormone

KW - Secretion

KW - Stomach

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Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat

Abstract

Keywords

ASJC Scopus subject areas

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