Advances in targeting the WNT/β-catenin signaling pathway in cancer

Avradip Chatterjee; Sayan Paul; Bharti Bisht; Shelley Bhattacharya; Sudhakar Sivasubramaniam; Manash K. Paul

doi:10.1016/j.drudis.2021.07.007

Advances in targeting the WNT/β-catenin signaling pathway in cancer

Avradip Chatterjee, Sayan Paul, Bharti Bisht, Shelley Bhattacharya, Sudhakar Sivasubramaniam, Manash K. Paul

Research output: Contribution to journal › Review article › peer-review

Abstract

WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the development of WNT/β-catenin inhibitors, available inhibitors, and their specific molecular interactions with the target proteins. We also discuss inhibitors that are in clinical trials and describe potential new avenues for therapeutically targeting the WNT/β-catenin pathway. Furthermore, we introduce emerging strategies, including artificial intelligence (AI)-assisted tools and technology-based actionable approaches, to translate WNT/β-catenin inhibitors to the clinic for cancer therapy.

Original language	English (US)
Pages (from-to)	82-101
Number of pages	20
Journal	Drug Discovery Today
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.drudis.2021.07.007
State	Published - Jan 2022
Externally published	Yes

Keywords

Artificial intelligence
Cancer
Challenges
Clinical trials
Drug design
Inhibitors
Natural products
Nuclear transport
Phase transition
Phosphorylation
Protein-small molecule interaction
Targeting protein-protein interaction
WNT/β-catenin signaling

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.drudis.2021.07.007

Cite this

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title = "Advances in targeting the WNT/β-catenin signaling pathway in cancer",

abstract = "WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the development of WNT/β-catenin inhibitors, available inhibitors, and their specific molecular interactions with the target proteins. We also discuss inhibitors that are in clinical trials and describe potential new avenues for therapeutically targeting the WNT/β-catenin pathway. Furthermore, we introduce emerging strategies, including artificial intelligence (AI)-assisted tools and technology-based actionable approaches, to translate WNT/β-catenin inhibitors to the clinic for cancer therapy.",

keywords = "Artificial intelligence, Cancer, Challenges, Clinical trials, Drug design, Inhibitors, Natural products, Nuclear transport, Phase transition, Phosphorylation, Protein-small molecule interaction, Targeting protein-protein interaction, WNT/β-catenin signaling",

author = "Avradip Chatterjee and Sayan Paul and Bharti Bisht and Shelley Bhattacharya and Sudhakar Sivasubramaniam and Paul, {Manash K.}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = jan,

doi = "10.1016/j.drudis.2021.07.007",

language = "English (US)",

volume = "27",

pages = "82--101",

journal = "Drug Discovery Today",

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AU - Chatterjee, Avradip

AU - Paul, Sayan

AU - Bisht, Bharti

AU - Bhattacharya, Shelley

AU - Sivasubramaniam, Sudhakar

AU - Paul, Manash K.

PY - 2022/1

Y1 - 2022/1

N2 - WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the development of WNT/β-catenin inhibitors, available inhibitors, and their specific molecular interactions with the target proteins. We also discuss inhibitors that are in clinical trials and describe potential new avenues for therapeutically targeting the WNT/β-catenin pathway. Furthermore, we introduce emerging strategies, including artificial intelligence (AI)-assisted tools and technology-based actionable approaches, to translate WNT/β-catenin inhibitors to the clinic for cancer therapy.

AB - WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the development of WNT/β-catenin inhibitors, available inhibitors, and their specific molecular interactions with the target proteins. We also discuss inhibitors that are in clinical trials and describe potential new avenues for therapeutically targeting the WNT/β-catenin pathway. Furthermore, we introduce emerging strategies, including artificial intelligence (AI)-assisted tools and technology-based actionable approaches, to translate WNT/β-catenin inhibitors to the clinic for cancer therapy.

KW - Artificial intelligence

KW - Cancer

KW - Challenges

KW - Clinical trials

KW - Drug design

KW - Inhibitors

KW - Natural products

KW - Nuclear transport

KW - Phase transition

KW - Phosphorylation

KW - Protein-small molecule interaction

KW - Targeting protein-protein interaction

KW - WNT/β-catenin signaling

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DO - 10.1016/j.drudis.2021.07.007

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ER -

Advances in targeting the WNT/β-catenin signaling pathway in cancer

Abstract

Keywords

ASJC Scopus subject areas

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