TY - JOUR
T1 - Administration of Nonsteroidal Anti-inflammatory Agents in Patients With Rheumatoid Arthritis
T2 - Effects on Indexes of Cellular Immune Status and Serum Rheumatoid Factor Levels
AU - Goodwin, James S.
AU - Ceuppens, Jan L.
AU - Rodriguez, Martin A.
N1 - Funding Information:
Thisinvestigationwassupportedinpartby grant AG 01245-04 from the Public Health Service. AnnGrant,ElsaGallegos,andJillFleig providedtechnicalassistance.JoyceCobbhelped preparethemanuscript.
PY - 1983/11/11
Y1 - 1983/11/11
N2 - We have previously reported that nonsteroidal anti-inflammatory agents (NSAIAs) stimulate cellular immune responses and inhibit production of IgM rheumatoid factor in cultures of lymphocytes from patients with rheumatoid arthritis. We had 20 patients with rheumatoid arthritis stop taking NSAIAs for two weeks and then take piroxicam, a new NSAIA, for an additional ten weeks to assess the in vivo effects of NSAIAs on cellular immunity and rheumatoid factor levels. In each case, serum rheumatoid factor levels rose and phytohemagglutinin response fell when placebo was substituted for NSAIAs. Piroxicam administration was associated with a fall in rheumatoid factor levels to approximately 62% of the baseline level and with an increase in phytohemagglutinin response. The action of NSAIAs in rheumatoid arthritis may be mediated to a degree by partial correction of the disordered immunoregulation in this disease.
AB - We have previously reported that nonsteroidal anti-inflammatory agents (NSAIAs) stimulate cellular immune responses and inhibit production of IgM rheumatoid factor in cultures of lymphocytes from patients with rheumatoid arthritis. We had 20 patients with rheumatoid arthritis stop taking NSAIAs for two weeks and then take piroxicam, a new NSAIA, for an additional ten weeks to assess the in vivo effects of NSAIAs on cellular immunity and rheumatoid factor levels. In each case, serum rheumatoid factor levels rose and phytohemagglutinin response fell when placebo was substituted for NSAIAs. Piroxicam administration was associated with a fall in rheumatoid factor levels to approximately 62% of the baseline level and with an increase in phytohemagglutinin response. The action of NSAIAs in rheumatoid arthritis may be mediated to a degree by partial correction of the disordered immunoregulation in this disease.
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U2 - 10.1001/jama.1983.03340180039022
DO - 10.1001/jama.1983.03340180039022
M3 - Article
C2 - 6226809
AN - SCOPUS:0020617721
SN - 0098-7484
VL - 250
SP - 2485
EP - 2488
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 18
ER -