Adenovirus-based genetic vaccines for biodefense

Julie L. Boyer; Gary Kobinger; James M. Wilson; Ronald G. Crystal

doi:10.1089/hum.2005.16.157

Adenovirus-based genetic vaccines for biodefense

Julie L. Boyer, Gary Kobinger, James M. Wilson, Ronald G. Crystal

Research output: Contribution to journal › Review article › peer-review

Abstract

The robust host responses elicited against transgenes encoded by E1 ^-E3^- adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

Original language	English (US)
Pages (from-to)	157-168
Number of pages	12
Journal	Human Gene Therapy
Volume	16
Issue number	2
DOIs	https://doi.org/10.1089/hum.2005.16.157
State	Published - Feb 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics

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10.1089/hum.2005.16.157

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abstract = "The robust host responses elicited against transgenes encoded by E1 -E3- adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.",

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AU - Crystal, Ronald G.

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AB - The robust host responses elicited against transgenes encoded by E1 -E3- adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

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Adenovirus-based genetic vaccines for biodefense

Abstract

ASJC Scopus subject areas

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