Adeno-associated virus serotype 9-expressed zmapp in mice confers protection against systemic and airway-acquired ebola virus infection

Maria P. Limberis, Anna Tretiakova, Kalyani Nambiar, Gary Wong, Trina Racine, Marco Crosariol, Qiu Xiangguo, Gary Kobinger, James M. Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.

Original languageEnglish (US)
Pages (from-to)1975-1979
Number of pages5
JournalJournal of Infectious Diseases
Volume214
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Keywords

  • Airway
  • Animals
  • Infectious disease
  • Prophylaxis
  • Protection
  • Vaccine
  • Vector
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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