Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

Yuri P. Vedernikov; Ancizar Betancourt; Melissa J. Wentz; George R. Saade; Robert E. Garfield

doi:10.1016/j.ajog.2005.05.006

Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

Yuri P. Vedernikov, Ancizar Betancourt, Melissa J. Wentz, George R. Saade, Robert E. Garfield

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: We tested the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V_1A (VP) receptors, and that this depends on pregnancy. Study design: Concentration-contraction relationships (CCR) to OT and VP (10^-12-10^-6 mol/L) were obtained in different blood vessels. CCR were obtained in uterine arteries (UA) from nonpregnant, mid-pregnant, and late pregnant rats (n = 6-10 per group) in the absence and presence of selective antagonists (10^-7 mol/L). Results: Sensitivity to OT, but not to VP, is attenuated in pregnant rat UA. Antagonists shifted CCR of OT and VP to the right, and, to a lesser extent, of the counterpart, in all UA. VP antagonist depresses oxytocin CCR much more than OT antagonist in pregnant rat UA. Conclusion: OT and VP contract UA via their own receptors, although partial cross-activation is evident. Adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.

Original language	English (US)
Pages (from-to)	252-260
Number of pages	9
Journal	American journal of obstetrics and gynecology
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2005.05.006
State	Published - Jan 2006

Keywords

Oxytocin
Receptors
Uterine artery
Vascular adaptation to pregnancy
Vasopressin

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2005.05.006

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title = "Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin",

abstract = "Objective: We tested the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V1A (VP) receptors, and that this depends on pregnancy. Study design: Concentration-contraction relationships (CCR) to OT and VP (10-12-10-6 mol/L) were obtained in different blood vessels. CCR were obtained in uterine arteries (UA) from nonpregnant, mid-pregnant, and late pregnant rats (n = 6-10 per group) in the absence and presence of selective antagonists (10-7 mol/L). Results: Sensitivity to OT, but not to VP, is attenuated in pregnant rat UA. Antagonists shifted CCR of OT and VP to the right, and, to a lesser extent, of the counterpart, in all UA. VP antagonist depresses oxytocin CCR much more than OT antagonist in pregnant rat UA. Conclusion: OT and VP contract UA via their own receptors, although partial cross-activation is evident. Adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.",

keywords = "Oxytocin, Receptors, Uterine artery, Vascular adaptation to pregnancy, Vasopressin",

author = "Vedernikov, {Yuri P.} and Ancizar Betancourt and Wentz, {Melissa J.} and Saade, {George R.} and Garfield, {Robert E.}",

year = "2006",

month = jan,

doi = "10.1016/j.ajog.2005.05.006",

language = "English (US)",

volume = "194",

pages = "252--260",

journal = "American journal of obstetrics and gynecology",

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T1 - Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

AU - Vedernikov, Yuri P.

AU - Betancourt, Ancizar

AU - Wentz, Melissa J.

AU - Saade, George R.

AU - Garfield, Robert E.

PY - 2006/1

Y1 - 2006/1

N2 - Objective: We tested the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V1A (VP) receptors, and that this depends on pregnancy. Study design: Concentration-contraction relationships (CCR) to OT and VP (10-12-10-6 mol/L) were obtained in different blood vessels. CCR were obtained in uterine arteries (UA) from nonpregnant, mid-pregnant, and late pregnant rats (n = 6-10 per group) in the absence and presence of selective antagonists (10-7 mol/L). Results: Sensitivity to OT, but not to VP, is attenuated in pregnant rat UA. Antagonists shifted CCR of OT and VP to the right, and, to a lesser extent, of the counterpart, in all UA. VP antagonist depresses oxytocin CCR much more than OT antagonist in pregnant rat UA. Conclusion: OT and VP contract UA via their own receptors, although partial cross-activation is evident. Adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.

AB - Objective: We tested the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V1A (VP) receptors, and that this depends on pregnancy. Study design: Concentration-contraction relationships (CCR) to OT and VP (10-12-10-6 mol/L) were obtained in different blood vessels. CCR were obtained in uterine arteries (UA) from nonpregnant, mid-pregnant, and late pregnant rats (n = 6-10 per group) in the absence and presence of selective antagonists (10-7 mol/L). Results: Sensitivity to OT, but not to VP, is attenuated in pregnant rat UA. Antagonists shifted CCR of OT and VP to the right, and, to a lesser extent, of the counterpart, in all UA. VP antagonist depresses oxytocin CCR much more than OT antagonist in pregnant rat UA. Conclusion: OT and VP contract UA via their own receptors, although partial cross-activation is evident. Adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.

KW - Oxytocin

KW - Receptors

KW - Uterine artery

KW - Vascular adaptation to pregnancy

KW - Vasopressin

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Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

Abstract

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