Acute ethanol administration selectively alters localized cerebral glucose metabolism

Michael J. Eckardt; Gerald A. Campbell; Cheryl A. Marietta; Edward Majchrowicz; Forrest F. Weight

doi:10.1016/0006-8993(88)90912-2

Acute ethanol administration selectively alters localized cerebral glucose metabolism

Michael J. Eckardt, Gerald A. Campbell, Cheryl A. Marietta, Edward Majchrowicz, Forrest F. Weight

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41 Scopus citations

Abstract

The effects of acute ethanol administration on glucose utilization in the CNS of rat were studied using the 2-deoxyglucose technique. Cerebral glucose utilization was determined for 53 brain regions at peak and descending blood ethanol concentrations averaging 14, 26 and 66 mM. Decreased glucose utilization was the predominant finding and was observed in 20% of the regions evaluated, with median raphe, vestibular nucleus, cerebellar vermis, and various structures associated with the auditory system showing the greatest reductions. The only structures that showed increased glucose utilization were the dentate region of the hippocampus and the superior olive, and this was only apparent at a blood ethanol concentration of 14 mM.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Brain Research
Volume	444
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90912-2
State	Published - Mar 15 1988
Externally published	Yes

Keywords

Cerebral metabolism
Deoxyglucose
Ethanol

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)90912-2

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title = "Acute ethanol administration selectively alters localized cerebral glucose metabolism",

abstract = "The effects of acute ethanol administration on glucose utilization in the CNS of rat were studied using the 2-deoxyglucose technique. Cerebral glucose utilization was determined for 53 brain regions at peak and descending blood ethanol concentrations averaging 14, 26 and 66 mM. Decreased glucose utilization was the predominant finding and was observed in 20% of the regions evaluated, with median raphe, vestibular nucleus, cerebellar vermis, and various structures associated with the auditory system showing the greatest reductions. The only structures that showed increased glucose utilization were the dentate region of the hippocampus and the superior olive, and this was only apparent at a blood ethanol concentration of 14 mM.",

keywords = "Cerebral metabolism, Deoxyglucose, Ethanol",

author = "Eckardt, {Michael J.} and Campbell, {Gerald A.} and Marietta, {Cheryl A.} and Edward Majchrowicz and Weight, {Forrest F.}",

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T1 - Acute ethanol administration selectively alters localized cerebral glucose metabolism

AU - Eckardt, Michael J.

AU - Campbell, Gerald A.

AU - Marietta, Cheryl A.

AU - Majchrowicz, Edward

AU - Weight, Forrest F.

PY - 1988/3/15

Y1 - 1988/3/15

N2 - The effects of acute ethanol administration on glucose utilization in the CNS of rat were studied using the 2-deoxyglucose technique. Cerebral glucose utilization was determined for 53 brain regions at peak and descending blood ethanol concentrations averaging 14, 26 and 66 mM. Decreased glucose utilization was the predominant finding and was observed in 20% of the regions evaluated, with median raphe, vestibular nucleus, cerebellar vermis, and various structures associated with the auditory system showing the greatest reductions. The only structures that showed increased glucose utilization were the dentate region of the hippocampus and the superior olive, and this was only apparent at a blood ethanol concentration of 14 mM.

AB - The effects of acute ethanol administration on glucose utilization in the CNS of rat were studied using the 2-deoxyglucose technique. Cerebral glucose utilization was determined for 53 brain regions at peak and descending blood ethanol concentrations averaging 14, 26 and 66 mM. Decreased glucose utilization was the predominant finding and was observed in 20% of the regions evaluated, with median raphe, vestibular nucleus, cerebellar vermis, and various structures associated with the auditory system showing the greatest reductions. The only structures that showed increased glucose utilization were the dentate region of the hippocampus and the superior olive, and this was only apparent at a blood ethanol concentration of 14 mM.

KW - Cerebral metabolism

KW - Deoxyglucose

KW - Ethanol

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JF - Brain Research

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Acute ethanol administration selectively alters localized cerebral glucose metabolism

Abstract

Keywords

ASJC Scopus subject areas

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