Acute doxorubicin-induced cardiac arrhythmias during ether anesthesia

R. C. Aversano; P. J. Boor

Acute doxorubicin-induced cardiac arrhythmias during ether anesthesia

R. C. Aversano, P. J. Boor

Research output: Contribution to journal › Article › peer-review

Abstract

Acute intravenous administration of doxorubicin (30 and 50 mg/kg) elicited cardiac arrhythmias in the mouse, the severity and extent of which were dependent upon dose of doxorubicin and the anesthetic agent utilized. Fatal arrhythmias occurred in all mice given 50 mg/kg doxorubicin under ether anesthesia. Vasoactive amines may mediate the arrhythmogenicity of acute doxorubicin administration.

Original language	English (US)
Pages (from-to)	345-348
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	41
Issue number	2
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

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title = "Acute doxorubicin-induced cardiac arrhythmias during ether anesthesia",

abstract = "Acute intravenous administration of doxorubicin (30 and 50 mg/kg) elicited cardiac arrhythmias in the mouse, the severity and extent of which were dependent upon dose of doxorubicin and the anesthetic agent utilized. Fatal arrhythmias occurred in all mice given 50 mg/kg doxorubicin under ether anesthesia. Vasoactive amines may mediate the arrhythmogenicity of acute doxorubicin administration.",

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year = "1983",

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AB - Acute intravenous administration of doxorubicin (30 and 50 mg/kg) elicited cardiac arrhythmias in the mouse, the severity and extent of which were dependent upon dose of doxorubicin and the anesthetic agent utilized. Fatal arrhythmias occurred in all mice given 50 mg/kg doxorubicin under ether anesthesia. Vasoactive amines may mediate the arrhythmogenicity of acute doxorubicin administration.

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AN - SCOPUS:0020593744

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Acute doxorubicin-induced cardiac arrhythmias during ether anesthesia

Abstract

ASJC Scopus subject areas

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