Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Jianyong Chen, Sin Park Chang, Shao Jun Tang

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-D-aspartate receptor-dependent synaptic Wnt3a release, nuclear β-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)11910-11916
Number of pages7
JournalJournal of Biological Chemistry
Issue number17
StatePublished - Apr 28 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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