Acetaminophen hepatotoxicity

T. A. Broughan, R. D. Soloway

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


To determine the influence of psychosocial factors in accidental and deliberate acetaminophen overdose, we reviewed the charts of 207 overdose patients, and 48 met our criteria for acetaminophen toxicity. Two patients died. A psychiatric history was present in 75%, and 25% had a previous or subsequent suicide attempt. A substance abuse history was elicited from 46%, and 36% of adolescent teenagers had a teen pregnancy. The mean time to starting N-acetylcysteine was 18.5 hr. Delayed N-acetylcysteine administration led to higher transaminase levels. Alcohol abuse was associated with a longer hospital stay. Mean AST was 8860 IU/liter in the accidental and 3013 IU/liter in the suicide groups. We concluded that management of acetaminophen toxicity can be optimized by early identification, obtaining a complete drug screen, starting N-acetylcysteine early or whenever toxic acetaminophen levels or elevated transaminases are identified, and referring patients with acetaminophen toxicity to a liver center.

Original languageEnglish (US)
Pages (from-to)1553-1558
Number of pages6
JournalDigestive Diseases and Sciences
Issue number8
StatePublished - 2000
Externally publishedYes


  • Acetaminophen
  • Alcohol
  • Liver
  • Overdose
  • Poisoning

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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