Acceleration of fetal lung maturation following prolonged rupture of the membranes

C. Joan Richardson, Jeffrey J. Pomerance, M. Douglas Cunningham, Louis Gluck

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Prolonged rupture of the membranes exerts an accelerating effect on fetal lung maturation independent of gestational age or birth weight and resulting in absence of the respiratory distress syndrome (RDS). Sixty-four true-premature infants born of mothers with no complications of pregnancy other than prolonged rupture of the membranes were evaluated for the presence of RDS. In 42 of these infants, membranes were ruptured 24 hours or less prior to delivery, and RDS occurred in 64 per cent. In 22 infants with membranes ruptured more than 24 hours prior to delivery, 31 per cent developed RDS. Lecithin/sphingomyelin ratios showed marked acceleration following membrane rupture, irrespective of gestational age.

Original languageEnglish (US)
Pages (from-to)1115-1118
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number8
StatePublished - Apr 15 1974
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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