Accelerated partial breast irradiation: Past, present, and future

Anne W. Tann, Sandra S. Hatch, Melissa M. Joyner, Lee R. Wiederhold, Todd A. Swanson

    Research output: Contribution to journalReview articlepeer-review

    13 Scopus citations

    Abstract

    Accelerated partial breast irradiation (APBI) focuses higher doses of radiation during a shorter interval to the lumpectomy cavity, in the setting of breast conserving therapy for early stage breast cancer. The utilization of APBI has increased in the past decade because of the shorter treatment schedule and a growing body of outcome data showing positive cosmetic outcomes and high local control rates in selected patients undergoing breast conserving therapy. Technological advances in various APBI modalities, including intracavitary and interstitial brachytherapy, intraoperative radiation therapy, and external beam radiation therapy, have made APBI more accessible in the community. Results of early APBI trials served as the basis for the current consensus guidelines, and multiple prospective randomized clinical trials are currently ongoing. The pending long term results of these trials will help us identify optimal candidates that can benefit from ABPI. Here we provide an overview of the clinical and cosmetic outcomes of various APBI techniques and review the current guidelines for selecting suitable breast cancer patients. We also discuss the impact of APBI on the economics of cancer care and patient reported quality of life.

    Original languageEnglish (US)
    Pages (from-to)370-379
    Number of pages10
    JournalWorld Journal of Clinical Oncology
    Volume7
    Issue number5
    DOIs
    StatePublished - Oct 10 2016

    Keywords

    • Accelerated partial breast irradiation
    • Breast cancer
    • Interstitial brachytherapy
    • Intracavitary brachytherapy

    ASJC Scopus subject areas

    • Oncology

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