AARC clinical practice guideline: Blood gas analysis and hemoximetry: 2013

Michael D. Davis, Brian K. Walsh, Steve E. Sittig, Ruben D. Restrepo

Research output: Contribution to journalArticlepeer-review


We searched MEDLINE, CINAHL, and Cochrane Library database for articles published between January 1990 and December 2012. The update of this clinical practice guideline is based on 237 clinical trials, 54 reviews, and 23 meta-analyses on blood gas analysis (BGA) and hemoximetry. The following recommendations are made following the Grading of Recommendations Assessment, Development, and Evaluation scoring system. BGA and hemoximetry are recommended for evaluating a patient's ventilatory, acid-base, and/or oxygenation status. BGA and hemoximetry are suggested for evaluating a patient's response to therapeutic interventions. BGA and hemoximetry are recommended for monitoring severity and progression of documented cardiopulmonary disease processes. Hemoximetry is recommended to determine the impact of dyshemoglobins on oxygenation. Capillary BGA is not recommended to determine oxygenation status. Central venous BGA and hemoximetry are suggested to determine oxygen consumption in the setting of early goaldirected therapies. For the assessment of oxygenation, a peripheral venous PO2 is not recommended as a substitute for an arterial blood measurement (PaO2). It is not recommended to use venous PCO2 and pH as a substitute for arterial blood measurement of PaCO2 and pH. It is suggested that hemoximetry is used in the detection and evaluation of shunts during diagnostic cardiac catheterization.

Original languageEnglish (US)
Pages (from-to)1694-1703
Number of pages10
JournalRespiratory care
Issue number10
StatePublished - Oct 1 2013
Externally publishedYes


  • Blood gas analysis
  • Blood gases
  • Guidelines
  • Hemoximetry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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