A Two-Component DNA-Prime/Protein-Boost Vaccination Strategy for Eliciting Long-Term, Protective T Cell Immunity against Trypanosoma cruzi

Keyphrases

• Trypanosoma Cruzi (T. cruzi) 100%
• Two-component 100%
• T Cell Immunity 100%
• DNA Prime 100%
• Vaccination Strategy 100%
• Protein Boost 100%
• Booster Immunization 100%
• Revaccination 75%
• Challenge Infection 75%
• Rapid Expansion 75%
• Cytotoxic T Lymphocytes 50%
• CD4+ 50%
• Vaccine Induced 50%
• CD8+ T Cells 50%
• T Cells 25%
• Recombinant 25%
• Protective Immunity 25%
• Infectious Diseases 25%
• Protective Efficacy 25%
• Interleukin-12 (IL-12) 25%
• Subunit Vaccine 25%
• Infected Mice 25%
• Effective Strategies 25%
• C57BL 25%
• Chagas Disease 25%
• Long-term Efficacy 25%
• Parasite Replication 25%
• Unvaccinated 25%
• Co-delivery 25%
• Antiparasite 25%
• Anti-T. Cruzi 25%
• Granulocyte Colony-stimulating Factor (G-CSF) 25%
• T. Cruzi Infection 25%
• Trypanosoma Cruzi Infection 25%
• Expression Plasmid 25%
• Specific Types 25%
• CD8+ 25%
• Memory Phenotype 25%
• Significant Benefit 25%
• T Lymphocyte Response 25%
• IL-1 Family Cytokines 25%
• Polyfunctional 25%
• Low Parasite Burden 25%
• Central Memory 25%

INIS

• proteins 100%
• dna 100%
• immunity 100%
• vaccines 100%
• trypanosoma 100%
• mice 50%
• expansion 50%
• parasites 50%
• phenotype 37%
• lymphocytes 25%
• production 12%
• diseases 12%
• control 12%
• data 12%
• tissues 12%
• cytokines 12%
• reduction 12%
• stimuli 12%
• delivery 12%
• plasmids 12%

Immunology and Microbiology

• Vaccine Efficacy 100%
• Adoptive Immunity 100%
• Trypanosoma Cruzi 100%
• Mouse 42%
• Phenotype 42%
• Parasite 42%
• Lymphocyte 28%
• CD4 28%
• CD8 28%
• Cytotoxic T-Cell 28%
• T Cell 14%
• Tissues 14%
• Cytokine 14%
• C57BL 6 Mouse 14%
• Immunity 14%
• Reduction (Chemistry) 14%
• Plasmid 14%
• Subunit Vaccine 14%
• Memory 14%
• T-Helper Cell 14%
• Chagas Disease 14%
• Parasite Load 14%
• Granulocyte Macrophage Colony-Stimulating Factor 14%