A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin

Hee Young Kim, Jigong Wang, Kyungsoon Chung, Jin Mo Chung

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - Sep 12 2008
Externally publishedYes


  • Animal model
  • Lateral ankle ligament injury
  • Pain
  • Weight bearing

ASJC Scopus subject areas

  • General Neuroscience


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