TY - JOUR
T1 - A serological survey of ebola virus infection in central African nonhuman primates
AU - Leroy, Eric M.
AU - Telfer, P.
AU - Kumulungui, B.
AU - Yaba, P.
AU - Rouquet, P.
AU - Roques, P.
AU - Gonzalez, J. P.
AU - Ksiazek, T. G.
AU - Rollin, P. E.
AU - Nerrienet, E.
N1 - Funding Information:
Financial support: The CIRMF is supported by the government of Gabon, Total-Fina-Elf Gabon, and the Ministère de la Coopération Franc¸aise. This work was supported by a Fonds de Solidarité Prioritaire grant from the Ministère des Affaires Etrangères de la France (2002005700) and the National Institutes of Health (grant R01 AI44596).
PY - 2004/12/1
Y1 - 2004/12/1
N2 - We used an ELISA to determine the prevalence of IgG antibodies specific for the Zaire subtype of Ebola virus in 790 nonhuman primates, belonging to 20 species, studied between 1985 and 2000 in Cameroon, Gabon, and the Republic of Congo. The seroprevalence rate of Ebola antibody in wild-born chimpanzees was 12.9%, indicating that (1) Ebola virus circulates in the forests of a large region of central Africa, including countries such as Cameroon, where no human cases of Ebola infections have been reported; (2) Ebola virus was present in the area before recent outbreaks in humans; (3) chimpanzees are continuously in contact with the virus; and (4) nonlethal Ebola infection can occur in chimpanzees. These results, together with the unexpected detection of Ebola-specific IgG in other species (5 drills, 1 baboon, 1 mandrill, and 1 Cercopithecus), may help to narrow the search for the reservoir of Ebola virus. They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region.
AB - We used an ELISA to determine the prevalence of IgG antibodies specific for the Zaire subtype of Ebola virus in 790 nonhuman primates, belonging to 20 species, studied between 1985 and 2000 in Cameroon, Gabon, and the Republic of Congo. The seroprevalence rate of Ebola antibody in wild-born chimpanzees was 12.9%, indicating that (1) Ebola virus circulates in the forests of a large region of central Africa, including countries such as Cameroon, where no human cases of Ebola infections have been reported; (2) Ebola virus was present in the area before recent outbreaks in humans; (3) chimpanzees are continuously in contact with the virus; and (4) nonlethal Ebola infection can occur in chimpanzees. These results, together with the unexpected detection of Ebola-specific IgG in other species (5 drills, 1 baboon, 1 mandrill, and 1 Cercopithecus), may help to narrow the search for the reservoir of Ebola virus. They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region.
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U2 - 10.1086/425421
DO - 10.1086/425421
M3 - Review article
C2 - 15529251
AN - SCOPUS:9444274144
SN - 0022-1899
VL - 190
SP - 1895
EP - 1899
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -