A physiological model for burn injury and resuscitation

George C. Kramer, Ghazal Arabi Darreh Dor, Chris Meador, Ali Tivay, Jin Oh Hahn, Jose Salinas, Ramin Bighamian

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A 1st-principles-inspired physiological model was developed that can predict the redistribution of fluid and albumin in the patient after thermal injury. The key components of the model include volume kinetics, renal function, and burn-induced perturbations in circulatory physiology. The model was developed in such a way that it can be fully characterized by the patient weight, height, and total burn surface area (TBSA) as well as a small set of model parameters to be individualized to predict the patient's response to thermal injury and resuscitation. Based on the underlying physics and constraints of organs, new mathematical functions were developed to describe the renal function and lymph return. A novel approach was employed to implement the effect of burn on the pertinent physiology of patients' body. The model was identified and tested using two groups of sheep undergoing burn injury and resuscitation. The results suggested that the model can boast acceptable accuracy in reproducing experimentally observed plasma volume and urinary output despite its simplicity. Such a model, after meeting the requirements on accuracy and physiological credibility, may facilitate the validation and testing of burn resuscitation protocols and closed-loop decision support systems.

Original languageEnglish (US)
Title of host publicationProceedings of the 11th International Conference on Computer Modeling and Simulation, ICCMS 2019 - Workshop 8th International Conference on Intelligent Computing and Applications, ICICA 2019
PublisherAssociation for Computing Machinery
Number of pages4
ISBN (Electronic)9781450366199
StatePublished - Jan 16 2019
Event11th International Conference on Computer Modeling and Simulation, ICCMS 2019 - Melbourne, Australia
Duration: Jan 16 2019Jan 19 2019

Publication series

NameACM International Conference Proceeding Series


Conference11th International Conference on Computer Modeling and Simulation, ICCMS 2019


  • Burn injury
  • Fluid therapy
  • Mathematical modeling
  • Simulation

ASJC Scopus subject areas

  • Software
  • Human-Computer Interaction
  • Computer Vision and Pattern Recognition
  • Computer Networks and Communications


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